Fresh analysis reveals that individuals who stop using new weight-loss injections like Wegovy and Mounjaro may regain lost weight far faster than those who halt traditional lifestyle regimens.
Published data in a leading medical journal shows that while obese people can lose a large proportion of their total mass while on the medication, the weight returns at an average rate of nearly a kilo each month after stopping.
"Individuals buying such medications need to be informed of the potential of rapid rebound weight gain when the therapy is stopped," stated expert Dr. Susan Jebb.
That rate of regain means a return to starting weight in about 18 months.
Weighing Therapies
The study, which looked at 37 of studies involving over 9,000 of participants, compared the outcomes of these new drugs with other pills.
The team emphasize that individuals who shed pounds through dieting typically experience a slower creep back—approximately 0.1 kg a month—post-intervention.
Explaining the Rapid Regain
Experts suggest the way of the injections is key to understanding the amplified rebound.
These medications imitate a natural hormone called GLP-1, which moderates hunger.
"Artificially providing GLP-1 concentrations far above than normal might result in the body to produce less of its endogenous GLP-1, and could diminish responsiveness to its effects," said Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this hormone supplement means hunger is unsuppressed, making overeating much more probable."
A Chronic Issue?
The NHS advise the jabs for individuals with weight-linked health risks, alongside recommended diet and exercise modifications.
Many experts argue that, considering the significant potential of weight regain, the therapy should be considered long-term.
This opinion is reinforced by drug manufacturers, who state that the findings "emphasize the persistent nature of excess weight," akin to managing diseases like high blood pressure.
User Experiences
Individuals who have stopped the medication explain a powerful resurgence of hunger.
"It felt as if a switch activating and you become ravenous," said one woman.
The struggle is worsened if patients have not adopted lasting dietary or behavioural modifications during treatment.
Growing Use
Survey data indicate that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with interest remaining high.
- Adoption is more common among females compared to men.
- The 40s and 50s demographic shows the greatest usage rates.
- Many obtain the drugs through private prescriptions rather than the NHS.
Finally, researchers stress that while these medications are effective agents for shedding pounds, they are not a permanent fix and lasting health benefits hinges on ongoing lifestyle management.
